• Laboratory of NeuroGlia

    Margaret Ho

    Institute of neuroscience

    NYCU, Taipei, Taiwan

    The comparative brain: courtesy of Dr. Frank Hirth of King’s College, London

    We study the brain cells "glia" in

    flies and mice

    courtesy of Yu-Ting Tsai

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    The comparative brain:

    courtesy of Dr. Frank Hirth of King's College, London

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    Glia in flies and mice

    courtesy of Dr. Honglei Wang

  • Our Story

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    Education:

    1999 Bachelor of Arts, Department of Molecular and Cellular Biology, Biochemistry University of California at Berkeley, USA

    2003 Department of Molecular and Cellular Biology Harvard University, USA

     

    Career:

    2024-present 

    Associate Professor, Institute of Neuroscience,

    National Yang Ming Chiao Tung University, Taipei

    2017-2024  

    Associate Professor, School of Life Sciences and Technology, ShanghaiTech University, Shanghai (tenured 2022.05)

    2010-2017   

    Distinguished Professor, School of Medicine,

    Tongji University, Shanghai

    2003-2010   

    Postdoctoral Fellow, Institute of Molecular Biology,

    Academia Sinica, Taipei

    1998-1999   

    Research Assistant, Department of Chemistry and Chemical Biology, Harvard University, Cambridge

     

    Honor:

    國科會112年度2030跨世代國際年輕傑出學者

    Representative Publications:

    1. Li T, Shi W, Ho MS*, Zhang YQ*, 2024, A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury, eLife, 10.7554/eLife.87258.2 (featured in Brainnews Wechat public forum).

    2. Wang L, Zhang S, Yi S, Ho MS*, 2023, A new regulator of autophagy initiation in glia, Autophagy, Aug 29;1-3, invited commentary.

    3. Wang M and Ho MS*, 2023, Profiling neurotransmitter-evoked glial responses by RNA-sequencing analysis, Front. Neural Circuits 17:1252759.

    4. Zhang S, Yi S, Wang L, Li S, Wang H, Song L, Ou J, Zhang M, Wang M, Zheng Y, Wang R, Yang K, Liu T, Ho MS*, 2023, Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia, Proc Natl Acad Sci USA, Jul18;120(29):e2301002120 (featured in Logical Thinking Neuroscience and BioArtMED Wechat public forums).

    5. Wang L, Wang H, Yi S, Zhang S, Ho MS*, 2022, A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival, Traffic, Oct;23(10):506-520 (featured on the Cover).

    6. Yang M, Wang H, Chen C, ZhangS, Wang M, Senapati B, Li S, Yi S, Wang L, Zhang M, Yin S, He Y, Xue L, Lin S, Ho MS*, 2021, Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body, Proc Natl Acad Sci USA, 118(23):e2020098118 (featured in Logical Thinking NeuroscienceWechat public forum).

    7. Yang M, Guo Y, Wang S, Chen C, Chang YH, Ho MS*, 2021, The F-Box protein CG5003 regulatesaxon pruning and the integrity of the Drosophila mushroom body, Front Mol Neurosci, 14:634784.

    8. Liu YJ*, Zhang T, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS*, Duan S, 2021, The noncanonical role of the proteasecathepsin D as a cofilin phosphatase, Cell Res, 31(7):801-813 (last corresponding author).

    9. Liu YJ*, Zhang T, Cheng D, YangJ, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*, Wang XD*, Duan S*, 2020, Late endosomes promote microgliamigration via cytosolic translocation of immature protease cathD, Sci Adv, 6(50):eaba5783.

    10. Hao X, Wang S, Lu Y, Yu W, LiP, Jiang D, Guo T, Li M, Li J, Xu J, Wu W, Ho MS*, Zhang L*,2020, Lola regulates Drosophila adult midgut homeostasis vianon-canonical hippo signaling, eLife, 9:e47542.
    11. Cao W, Song L, Cheng J, Yi N,Cai L, Huang FD, Ho MS*, 2017, An automated rapid iterativenegative geotaxis assay for analyzing adult climbing behavior in a Drosophila model of neurodegeneration, J Vis Exp, (127):56507.

    12. Xiao X, Chen C, Yu TM, Ou J,Rui M, Zhai Y, He Y, Xue L, Ho MS*, 2017, Molecular chaperone Calnexin regulates the function of Drosophila sodium channel Paralytic, Front Mol Neurosci, 10:57.
    13. Chen C, Yin S, Cao W, Ho MS*, 2017, Drosophila ubiquitin E3 ligase dSmurf is required for synapse remodeling and axon pruning by glia, J Genet Genomics, 44(1):67-70.
    14. Xi X, Lu L, Zhuge CC, Chen X,Zhai Y, Cheng J, Mao H, Yang CC, Tan BC, Lee YN, Chien CT, Ho MS*, 2017, The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation, Sci Rep, 7:39856.
    15. Song L, He Y, Ou J, Zhao Y, LiR, Cheng J, Lin CH, Ho MS*, 2017, Auxilin underlies progressive locomotor deficits and dopaminergic neuron loss in a Drosophila model of Parkinson's disease, Cell Rep, 18(5):1132-1143.

  • Travelers/Lab members

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    Yi-Hua Lee

    Master

    Expertise:Radiation induced DNA damage response

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    Yu-Tung Lin

    Master

    Expertise:Biochemistry, Program information

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    Chia-Ching Lin

    Master 

    Expertise:

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    Yi-Hsuan Cheng

    Master 

    Expertise:decision-making

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    Yu-Ting Tsai

    Research Assistant

    Expertise:Neurodegenerative diseases, Emotion

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    You!

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    Alumni

    Undergraduate Students Master Students Ph.D. Students Research Associates

    Tianming Yu 2011-2014 Haian Mao 2010-2013 Changyan Chen 2012-2017 Jingjing Cheng 2014-2019

    Haiqin Zhang 2011-2013 Jiayao Ou 2012-2015 Xi Xiao 2013-2018 Shiping Zhang 2017-2024

    Jiaqi Wu 2011-2013 Zongbao Gao 2012-2015 Mengying Yang 2017-2021 Min Zhang 2017-2024

    Yijing He 2012-2016 Xuebing Chen 2014-2017 Honglei Wang 2017-2024

    Yunfeng Song 2013-2014 Li Song 2015-2018 Mengxiao Wang 2018-2024

    Wenwen Wang 2013-2014 Shuhua Li 2018-2021                        Shuanglong Yi 2018-2023

    Yichao Chen 2013-2014 Yuchen Zheng 2020-2024 Linfang Wang 2019-2024

    Jiajun Deng 2013-2015 Ruiqi Wang 2020-2023

    Ruoyu Li 2014-2016 Yutong Yang 2021-2024

    Shuai Yi 2014-2016

    Yongbo Zhao 2014-2016

    Luyi Chai 2014-2016 

     

    Ho Lab: Shanghai Branch

    2010-2023