Laboratory of NeuroGlia
Margaret Ho
Institute of neuroscience
NYCU, Taipei, Taiwan
We study the brain cells "glia" in
flies and mice
courtesy of Yu-Ting Tsai
The comparative brain:
courtesy of Dr. Frank Hirth of King's College, London
Glia in flies and mice
courtesy of Dr. Honglei Wang
Our Story
Education:
1999 Bachelor of Arts, Department of Molecular and Cellular Biology, Biochemistry University of California at Berkeley, USA
2003 Department of Molecular and Cellular Biology Harvard University, USA
Career:
2024-present
Associate Professor, Institute of Neuroscience,
National Yang Ming Chiao Tung University, Taipei
2017-2024
Associate Professor, School of Life Sciences and Technology, ShanghaiTech University, Shanghai (tenured 2022.05)
2010-2017
Distinguished Professor, School of Medicine,
Tongji University, Shanghai
2003-2010
Postdoctoral Fellow, Institute of Molecular Biology,
Academia Sinica, Taipei
1998-1999
Research Assistant, Department of Chemistry and Chemical Biology, Harvard University, Cambridge
Honor:
國科會112年度2030跨世代國際年輕傑出學者
Representative Publications:
1. Li T, Shi W, Ho MS*, Zhang YQ*, 2024, A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury, eLife, 10.7554/eLife.87258.2 (featured in Brainnews Wechat public forum).
2. Wang L, Zhang S, Yi S, Ho MS*, 2023, A new regulator of autophagy initiation in glia, Autophagy, Aug 29;1-3, invited commentary.
3. Wang M and Ho MS*, 2023, Profiling neurotransmitter-evoked glial responses by RNA-sequencing analysis, Front. Neural Circuits 17:1252759.
4. Zhang S, Yi S, Wang L, Li S, Wang H, Song L, Ou J, Zhang M, Wang M, Zheng Y, Wang R, Yang K, Liu T, Ho MS*, 2023, Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia, Proc Natl Acad Sci USA, Jul18;120(29):e2301002120 (featured in Logical Thinking Neuroscience and BioArtMED Wechat public forums).
5. Wang L, Wang H, Yi S, Zhang S, Ho MS*, 2022, A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival, Traffic, Oct;23(10):506-520 (featured on the Cover).
6. Yang M, Wang H, Chen C, ZhangS, Wang M, Senapati B, Li S, Yi S, Wang L, Zhang M, Yin S, He Y, Xue L, Lin S, Ho MS*, 2021, Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body, Proc Natl Acad Sci USA, 118(23):e2020098118 (featured in Logical Thinking NeuroscienceWechat public forum).
7. Yang M, Guo Y, Wang S, Chen C, Chang YH, Ho MS*, 2021, The F-Box protein CG5003 regulatesaxon pruning and the integrity of the Drosophila mushroom body, Front Mol Neurosci, 14:634784.
8. Liu YJ*, Zhang T, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS*, Duan S, 2021, The noncanonical role of the proteasecathepsin D as a cofilin phosphatase, Cell Res, 31(7):801-813 (last corresponding author).
9. Liu YJ*, Zhang T, Cheng D, YangJ, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*, Wang XD*, Duan S*, 2020, Late endosomes promote microgliamigration via cytosolic translocation of immature protease cathD, Sci Adv, 6(50):eaba5783.
10. Hao X, Wang S, Lu Y, Yu W, LiP, Jiang D, Guo T, Li M, Li J, Xu J, Wu W, Ho MS*, Zhang L*,2020, Lola regulates Drosophila adult midgut homeostasis vianon-canonical hippo signaling, eLife, 9:e47542.
11. Cao W, Song L, Cheng J, Yi N,Cai L, Huang FD, Ho MS*, 2017, An automated rapid iterativenegative geotaxis assay for analyzing adult climbing behavior in a Drosophila model of neurodegeneration, J Vis Exp, (127):56507.12. Xiao X, Chen C, Yu TM, Ou J,Rui M, Zhai Y, He Y, Xue L, Ho MS*, 2017, Molecular chaperone Calnexin regulates the function of Drosophila sodium channel Paralytic, Front Mol Neurosci, 10:57.
13. Chen C, Yin S, Cao W, Ho MS*, 2017, Drosophila ubiquitin E3 ligase dSmurf is required for synapse remodeling and axon pruning by glia, J Genet Genomics, 44(1):67-70.
14. Xi X, Lu L, Zhuge CC, Chen X,Zhai Y, Cheng J, Mao H, Yang CC, Tan BC, Lee YN, Chien CT, Ho MS*, 2017, The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation, Sci Rep, 7:39856.
15. Song L, He Y, Ou J, Zhao Y, LiR, Cheng J, Lin CH, Ho MS*, 2017, Auxilin underlies progressive locomotor deficits and dopaminergic neuron loss in a Drosophila model of Parkinson's disease, Cell Rep, 18(5):1132-1143.Travelers/Lab members
Yi-Hua Lee
Master
Expertise:Radiation induced DNA damage response
Yu-Tung Lin
Master
Expertise:Biochemistry, Program information
Chia-Ching Lin
Master
Expertise:
Yi-Hsuan Cheng
Master
Expertise:decision-making
Yu-Ting Tsai
Research Assistant
Expertise:Neurodegenerative diseases, Emotion
You!
Alumni
Undergraduate Students Master Students Ph.D. Students Research Associates
Tianming Yu 2011-2014 Haian Mao 2010-2013 Changyan Chen 2012-2017 Jingjing Cheng 2014-2019
Haiqin Zhang 2011-2013 Jiayao Ou 2012-2015 Xi Xiao 2013-2018 Shiping Zhang 2017-2024
Jiaqi Wu 2011-2013 Zongbao Gao 2012-2015 Mengying Yang 2017-2021 Min Zhang 2017-2024
Yijing He 2012-2016 Xuebing Chen 2014-2017 Honglei Wang 2017-2024
Yunfeng Song 2013-2014 Li Song 2015-2018 Mengxiao Wang 2018-2024
Wenwen Wang 2013-2014 Shuhua Li 2018-2021 Shuanglong Yi 2018-2023
Yichao Chen 2013-2014 Yuchen Zheng 2020-2024 Linfang Wang 2019-2024
Jiajun Deng 2013-2015 Ruiqi Wang 2020-2023
Ruoyu Li 2014-2016 Yutong Yang 2021-2024
Shuai Yi 2014-2016
Yongbo Zhao 2014-2016
Luyi Chai 2014-2016
Ho Lab: Shanghai Branch
2010-2023